Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Avenue, SL-419, Boston, MA, 02215, USA; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico of Rome, 00128 Rome, Italy. Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Avenue, SL-419, Boston, MA, 02215, USA. Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Avenue, SL-419, Boston, MA, 02215, USA. Electronic address: cmantzor@bidmc.harvard.edu.